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Effect of smoking on age at the time of coronary artery bypass graft surgery; baseline data results from the ROSETTA-CABG registry
  1. Rashid Chaudhry1,
  2. Fahd A Chaudhry2,
  3. Thao Huynh3,
  4. Ellis Lader4,
  5. Saira Rashid5,
  6. Karen Okrainec6,
  7. Karen Wou6,
  8. Mark J Eisenberg7,8,
  9. for the ROSETTA-CABG Investigators
  1. 1Department of Cardiology, Lahore 54590, Pakistan
  2. 2University Physician Health Care, University of Arizona, Tucson, Arizona, USA
  3. 3Division of Cardiology, Montreal General Hospital, Montreal, Quebec, Canada
  4. 4Mid Valley Cardiology, Kingston, New York, USA
  5. 5King Edward Medical University, Lahore, Pakistan
  6. 6Division of Internal Medicine, McGill University Health Center, Montreal, Quebec, Canada
  7. 7Divisions of Cardiology and Clinical Epidemiology, Jewish General Hospital, Montreal, Quebec, Canada
  8. 8Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada
  1. Correspondence to Dr M Rashid Chaudhry, 15-A Gosha-E-Ahbab Society, New Campus, Lahore 5490, Pakistan; rashid_chaudhry{at}


Background Coronary artery disease (CAD) is a leading cause of death. The aetiology of this disease is not known, but many important risk factors have been recognised.

Objective To evaluate the effect of smoking on age at the time of coronary artery bypass graft surgery (CABG), and to examine this finding in the light of medical literature.

Methods The authors recruited patients immediately after CABG in a prospective, study in 16 centres and enrolled 408 patients, of which 395 were ultimately analysed.

Results Among the 395 patients analysed, there were 60 smokers and 335 non-smokers. The smokers were 8.4 years younger than non-smokers at the time of index CABG. The average age of smokers was 55.79.0 years, and that of non-smokers was 64.1±9.9 years (p<0.001). Hyperlipidaemia was present in 76.7% of smokers and 74.6% of non-smokers (p—NS). Hypertension was present in 58.3% of smokers and 63.9% of non-smokers (p—NS). Diabetes mellitus was present in 21.3% of smokers and 29.3% of non smokers (p—NS). Left ventricular ejection fraction was 53.0±10.5% in smokers and 53.3 ±13.8% in non-smokers (p—NS). Myocardial infarction had occurred in 41.7% of smokers and 35.5% of non-smokers (p—NS).

Conclusion Smoking accelerates atherosclerosis and coronary thrombosis resulting in severe form of CAD that cannot be managed by medications or PCI, and requires coronary artery bypass graft surgery (CABG) 8.4 years earlier than non-smokers.

  • Smokers
  • atherosclerosis
  • coronary artery disease
  • coronary artery bypass graft
  • risk factors
  • acute myocardial infarction

Statistics from


  • Competing interests None.

  • Patient consent Obtained.

  • Ethics approval Ethics approval was provided by the ethical committees of the participating centres at local level.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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